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CellRank 2: Unified fate mapping in multiview single-cell data
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CellRank is a modular framework to study cellular dynamics based on Markov state modeling of
multi-view single-cell data. See our documentation
, and the CellRank 1
and CellRank 2 manuscript
_ to learn more.
See here <https://github.com/theislab/cellrank/blob/main/docs/about/cite.rst>
_ for how to properly cite our work.
CellRank scales to large cell numbers, is fully compatible with the scverse
_ ecosystem, and easy to use.
In the backend, it is powered by pyGPCCA
_ (Reuter et al. (2018)
). Feel
free to open an issue
or send us an email
_ if you encounter a bug, need our help or just
want to make a comment/suggestion.
CellRank's key applications
- Estimate differentiation direction based on a varied number of biological priors, including RNA velocity
(
La Manno et al. (2018)
, Bergen et al. (2020)
), any pseudotime or developmental potential,
experimental time points, metabolic labels, and more. - Compute initial, terminal and intermediate macrostates.
- Infer fate probabilities and driver genes.
- Visualize and cluster gene expression trends.
- ... and much more, check out our
documentation
_.
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.. _La Manno et al. (2018): https://doi.org/10.1038/s41586-018-0414-6
.. _Bergen et al. (2020): https://doi.org/10.1038/s41587-020-0591-3
.. _Reuter et al. (2018): https://doi.org/10.1021/acs.jctc.8b00079
.. _scverse: https://scverse.org/
.. _pyGPCCA: https://github.com/msmdev/pyGPCCA
.. _CellRank 1: https://www.nature.com/articles/s41592-021-01346-6
.. _CellRank 2 manuscript: https://doi.org/10.1101/2023.07.19.549685
.. _documentation: https://cellrank.org
.. _email: mailto:info@cellrank.org
.. _issue: https://github.com/theislab/cellrank/issues/new/choose