MoNvIso is a comprehensive software tool designed for the analysis and modeling of protein isoforms. It automates the process of identifying canonical and additional isoforms, assessing their modeling propensity, mapping mutations accurately, and building structural models of proteins.
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MoNvIso is a comprehensive software tool designed for the analysis and modeling of protein isoforms. It automates the process of identifying canonical and additional isoforms, assessing their modeling propensity, mapping mutations accurately, and building structural models of proteins. By leveraging data from the Uniprot database, MoNvIso facilitates a deeper understanding of protein function and variation.
Download uniprot_sprot.fasta and uniprot_sprot_varsplic.fasta from UniProt.
Write a mutation.txt file with the gene name and the mutations you are interested in (e.g.,):
GRIN1
R 844 C
Ala 349 Thr
Pro 578 Arg
Ser 688 Tyr
Tyr 647 Ser
GRIN2B
E413G
C436R
M1342R
L1424F
PRO1439ALA
DB_LOCATION=./
COBALT_HOME=./ncbi-cobalt-3.0.0/bin/
HMMER_HOME=/usr/local/bin/
PESTO_HOME=./PeSTO/
MODELLER_EXEC=mod10.5
RESOLUTION=4.50
SEQID=25
HMM_TO_IMPORT=100
MODEL_CUTOFF=5
PDB_TO_USE=10
NUM_OF_MOD_WT=1
NUM_OF_MOD_MUT=1
W_STRUCT=10
W_MUT=10
$ monviso isoform -i mutations.txt -o out/ -pf parameters.dat
Read the CONTRIBUTING.md file.
FAQs
MoNvIso is a comprehensive software tool designed for the analysis and modeling of protein isoforms. It automates the process of identifying canonical and additional isoforms, assessing their modeling propensity, mapping mutations accurately, and building structural models of proteins.
We found that monviso demonstrated a healthy version release cadence and project activity because the last version was released less than a year ago. It has 1 open source maintainer collaborating on the project.
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