opentargets-mcp

Open Targets MCP

Keyless MCP server for Open Targets: gene/disease/drug search, target details, disease associations.

Pairs well with mygene-mcp, ensembl-mcp, uniprot-mcp, clinvar-mcp, and reactome-mcp.

Quick start

npm install
npm run build
node dist/index.js

The server uses stdio, so it can be connected to Claude Desktop, Cursor, VS Code, MCP Inspector, or another compatible MCP client.

Tools at a glance

• search: Genes, diseases, drugs.
• get_target: Functions, known drugs, top diseases with scores.

Limits and privacy

This project is intentionally narrow. It should be treated as a practical helper, not a complete certification or security audit. Check the implementation and the returned data before using it with sensitive material. No credentials are required.

Premium tools

These tools need a license key:

• target_druggability
• target_pathways

Buy a key at https://mcp-marketplace.io/server/io-github-mrfentmen-opentargets-mcp and set it in your MCP client config:

"env": { "MCP_LICENSE_KEY": "mcp_live_..." }

The key is checked against MCP Marketplace, cached for 24 hours, and keeps working offline once one check has succeeded. Every other tool on this server stays free.